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Nicotine itself isn't addictive, but it's accountable for releasing dopamine, a neurotransmitter associated with pleasure and reinforcements in the mind, thus inducing addictive tendencies in humans. Nicotine is just a chemical within tobacco leaf, the main ingredient in cigarettes and is said to cause addiction and disease in cigarette smokers, (World Health Organization (WHO)).

Nicotine mimics the activities of acetylcholine, a naturally occurring neurotransmitter in the central nervous system and the nerve-muscle junction of skeletal muscles. Acetylcholine is accountable for excitability, that causes increase heart rate, alertness, and reaction times, (Psychopharmacology (Berl). 1989; 97(2):257-61.). Because acetylcholine and nicotine are chemically similar, they trigger exactly the same cholinergic receptors in the brain. The nicotine-acetylcholine receptors contain nerve endings that release dopamine when coupled or bind with nicotine or acetylcholine. Receptors are like cups having the actual dimensions that'll fit a neurotransmitter molecule, such as <a href="https://pod1688.com/">บุหรี่ไฟฟ้า Pod</a>.

The cup itself is lined with nerve endings (tips of neurons). It is these nerve endings that release dopamine once the neurotransmitter acetylcholine binds with the cup-like acetylcholine receptors (cholinergic receptors). A reinforcing and reward phenomenon of dopamine develops as the dopamine that is released from the nerve endings initiates a sense of pleasure in the individual's brain. The reinforcement mechanism is initiated once the brain becomes dependent on the pleasure caused by the dopamine that is released from the cholinergic receptors. This means that the mind is continually seeking to be pleasured. So, what'll happen in case of cigarette smokers is that they can continue to smoke cigarettes so the nicotine from the cigarette can induce the release of dopamine in the mind, causing them to feel happy each time they smoke a cigarette, (Nature Reviews Neuroscience 7, 967-975 (December 2006)).

Initially cigarette smokers smoked cigarettes there were just a few cholinergic receptors available as the natural action of acetylcholine only needs the normal level of receptors provided naturally to do its job. However, the increase concentration of nicotine available caused the normal levels of cholinergic receptors to become desensitized to the current presence of the increased quantity of nicotine in the cholinergic receptors. This desensitization causes the production or growth and development of more cholinergic receptors. These extra cholinergic receptors will soon become desensitized from the surplus nicotine available. Such processes occur until equilibrium is reached. Equilibrium is reached when cigarette smokers decide on the total amount of cigarettes they'll consume or smoke in certain day. At the moment, a fixed level of receptors is likely to be available for the addiction to continue. Smokers will normally say they smoke a couple of packs per day. They said so because of the level of receptors available to allow for two packs of cigarettes in a day.

A detrimental effect of all this really is the truth that such large levels of cholinergic receptors are available these days and hungry for nicotine. So, they could stimulate dopamine to pleasure the cigarette smoker. That is the reason why cigarette smokers have a very difficult time quitting. The very best approach therefore for a cigarette smoker to use within quitting is to gradually scale back on the total amount of cigarettes smoked in certain time interval.

As well as the dopamine-inducing effect of nicotine, is the speeding-up of one's heart rate by nicotine every time a cigarette is smoked. From the medical perspective, constantly having a synthetic upsurge in heart rate isn't a good idea either. For something, a continuing upsurge in heart rate by drugs such as nicotine may cause heart disease, (WHO).

Based on the World Health Organization, tobacco use contributes to diseases affecting one's heart and lungs, such as heart attacks, strokes, chronic obstructive pulmonary disease (COPD), emphysema, and cancer. Most cigarette induced cancers are lung cancer, cancers of the larynx, mouth, and pancreas. Cigarette smoke also causes myocardial infarctions, peripheral vascular disease and hypertension. The World Health Organization estimates that tobacco is accountable for about 5.4 million deaths in 2004 and about 100 million deaths throughout the 20th century.

As well as its addictive effects on the central nervous system, cigarette smoke contains numerous cancer-causing agents. They work by binding to DNA causing many genetic mutations. Nicotine might be the main culprit that is doing the binding to DNA causing genetic mutations, that leads to cancer. Nicotine is said to disrupt the natural processes of apoptosis (programmed cell death) by binding to DNA in cells, (National Institute of Health (NIH)). Defective cells contain junk DNA and other waste materials. When apoptosis is inhibited, natural cell death does not occur; instead, defective cells are allowed to proliferate or grow larger, uncontrollably. This is what happens in cancer and the key reason why cigarette smokers are more susceptible to developing cancers.

When apoptosis is uncontrollably triggered by chemicals, such as nicotine, it causes normal cells to die off. This could possibly be what is happening in one's heart tissues of cigarette smokers who suffer from heart disease and is also what is taking devote the extremities of cigarette smokers, who often complain of excessive coldness within their fingers, arms, toes, and legs, where circulation is lowest.

There are no existing studies to aid this exact explanation. However, on the basis of the familiarity with known scientific proof of apoptosis and the upsurge in death rates of cigarette smokers, this hypothetical explanation has some credence; and will continue to possess credence until proven otherwise! There is something deadly that is happening to cigarette smokers and nicotine is one of the agents behind it.

The tar in cigarette smoke can also be an agent that sucks the life out of cigarette smokers. The lung of a cigarette smoker is as black as along with of asphalt. It is like a serious bit of burnt pot roast. For this reason most cigarette smokers have difficulty breathing. It is hard for air to pass freely down the airways of smokers. The sad thing is that it is hard for cigarette smokers to quit. So, they continue later on of destruction, day after day, puffing on the silent killer--cigarette smoking.

One very important means to fix quitting smoking is smoking one less cigarette a day or even one less cigarette in a month if one less cigarette a day is too steep of a change to the deadly habit. If one normally smokes a group of cigarettes a day, that individual should remove one of those cigarettes and discard it--throw it in the trash can. Understand that the smoking of cigarettes started gradually. No-one started smoking a group of cigarettes a day because awful beginning stage of smoking cigarettes. Smoking one less cigarette per a specific time period will help get rid of the excessive cholinergic receptors that nicotine so dearly craves.

Wellbutrin is another method for helping people stop smoking. Wellbutrin is an antidepressant drug employed by individuals with depression. However, it's very potent in aiding people kick the deadly habit of cigarette smoking. It can be taken while smoking, unlike other smoking cessation agents. Wellbutrin blocks nicotine receptors and weakens the action of dopamine reuptake by neurons, (J Pharmacol Exp Ther. 2000 Oct; 295(1):321-7.).

Cigarette smokers who are interested in quitting should implement a workout program within their schedule because having less nicotine in ex-cigarette smokers causes weight-gain. Just how do we realize this? Former cigarette smokers who kicked the habit complain of putting on weight after they quit smoking. Ask any ex-cigarette smoker. One will hear exactly the same thing. Nicotine induces weight-loss in smokers. For this reason most cigarette smokers are skinny or slim. In case a cigarette smoker is overweight while smoking cigarettes, then see your face should seek medical attention because there could be a very dangerous medical condition lurking in the <a href="https://pod1688.com/">บุหรี่ไฟฟ้า Pod</a>.

Glenford S Robinson, BS, CLS (ASCP), is just a Clinical Laboratory Scientist, Journalist (American Chronicle), and Staff Writer for Mstardom.com [http://www.myspacestardom.com/newsindex], a social networking website and articles directory providing its members and visitors with up-to-the-minute news and entertainment and the ability to submit articles free.