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I am not an old crack but from time to time I suffer from attacks of gout. When it makes me feel really miserable I take allopurinol, but I do not observe any regimen. May be if I would, the attacks would step away. I'll try it next month!
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Allopurinol is metabolized to oxypurinol which is also an inhibitor of xanthine oxidase; allopurinol acts on purine catabolism, reducing the production of uric acid without disrupting the biosynthesis of vital purines.
The response is evaluated after approximately 48 hours of therapy and a dosage adjustment is made if necessary.
Allopurinol cannot be used in patients with hypersensitivity to the medication, in individuals with a hepatic or renal disorders, primary hemochromatosis, asymptomatic hyperuricemia, acute gout, pregnancy, lactation.
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Gout is a metabolic disorder which is characterized by hyperuricemia and resultant deposition of monosodium urate in the tissues, particularly the joints and kidneys.
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RCT (the Febuxostat versus Allopurinol Controlled Trial (FACT) trial) including 762 participants with gout (as per ARA criteria) that compared allopurinol 300 mg daily with febuxostat 80 or 120 mg daily.
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Contact your doctor if you experience frequent or severe gout attacks.
No significant differences between serum uric acid levels after fractionated and single-dose administration, neither were there differences in the aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase, leukocyte and thrombocyte figures.
The clearance of oxipurinol is increased by uricosuric drugs, and as a consequence, the addition of uricosuric agent reduces to some degree the inhibition of xanthine oxidase by oxipurinol and increases to some degree the urinary excretion of uric acid.
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Even with adequate therapy with Allopurinol it may require several months to deplete the uric acid pool sufficiently to achieve control of the acute attacks.
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However, about 2% of people develop hypersensitivity reactions (), and 20% of those are severe, including rash, toxic epidermal necrolysis, hepatitis, interstitial nephritis and death ().
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One participant initially in the placebo group had a hypersensitivity reaction with rash, fever and mild transaminitis leading to discontinuation of allopurinol at day 30 (), and we have excluded from the data analysis as both placebo and allopurinol were given to this participant.
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In rare cases Allopurinol can cause damage to nerve, kidney, and bone marrow as well as be a reason to a serious and even fatal allergic liver toxicity.
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Instead of asking whether you had an attack of gout during the study period, it should have been "HOW MANY attacks did you have over the study period?
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The FDA reported the incidence of adverse reactions was less than 1%, and that the most common adverse reaction to allopurinol is skin rash, recommending treatment be discontinued immediately if a rash develops.
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We considered allopurinol compared with placebo as the main comparison, and present results fully below.
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Deux études ont comparé différentes doses ou différentes méthodes d'administration de l'allopurinol.
While this review shows there may be similar effects when allopurinol was compared with benzbromarone for serum urate normalisation (moderate-quality evidence), it does provide moderate-quality evidence from one trial (57 participants) that allopurinol is probably more effective than placebo, and low-quality evidence based on four studies (2618 participants) that allopurinol 100 to 300 mg daily may be less effective than febuxostat 80 mg daily in achieving a target serum urate level at 24 to 52 weeks.
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At any sign of allergic reaction stop taking the medication and consult your doctor as development of serious skin disease, irreversible damage to the liver, or generalized inflammation of a blood or lymph vessel is possible in some individuals.
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Although the mechanism responsible for this has not been established, patients with impaired renal function should be carefully observed during the early stages of administration of Allopurinol and dosage decreased or the drug withdrawn if increased abnormalities in renal function appear and persist.
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Therapy in such patients should be carefully assessed initially and reassessed periodically to determine in each case that treatment is beneficial and that the benefits outweigh the risks.
There was low-quality evidence that there may be no difference in tophus regression between allopurinol up to 300 mg daily and febuxostat 80 mg daily.
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RCT (the APEX trial) including 1072 participants, with gout as per ARA criteria, and compared allopurinol 300 or 100 mg daily based on renal function with febuxostat 80, 120 or 240 mg daily or placebo.
The remaining four trials compared allopurinol with other treatments.
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