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Reduction in the quantity of bone or atrophy of skeletal tissue; a widespread age-related disorder characterized by decreased bone mass and loss of normal skeletal microarchitecture, leading to increased susceptibility to fractures.
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We used an elaborate user only study design to eliminate drug channelling bias and embedded two case control studies in a longitudinal open cohort study of alendronate use to achieve optimum statistical power for this rare fracture outcome.
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These events, lasting no more than 2 to 3 days and responding to acetaminophen, are consistent with an acute-phase response that has been reported in patients receiving bisphosphonates, including alendronate sodium.
We also examined interactions between variables.
Cyclical etidronate (Didronel) has fewer upper GI side effects but more lower GI side effects than alendronate.
It is in the 15 November 2011 issue of Annals of Internal Medicine (volume 155, pages 668-679).
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Injury to the bone in these patients via tooth extraction, dental surgery, or mechanical trauma is thought to initiate bisphosphonate-related osteonecrosis of the jaw (BRONJ).
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