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Women with elevated, but not postmenopausal, FSH levels are still at risk for pregnancy, and contraception should continue to be used until FSH levels remain in the postmenopausal range.

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Effects of teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: Thirty-six-month results of a randomized, double-blind, controlled trial.

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Risk of fracture among women who lose bone density during treatment with alendronate.

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Reduction in the quantity of bone or atrophy of skeletal tissue; a widespread age-related disorder characterized by decreased bone mass and loss of normal skeletal microarchitecture, leading to increased susceptibility to fractures.

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We used an elaborate user only study design to eliminate drug channelling bias and embedded two case control studies in a longitudinal open cohort study of alendronate use to achieve optimum statistical power for this rare fracture outcome.

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Several studies have addressed the effects of bisphosphonates on indirect bone healing.

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These events, lasting no more than 2 to 3 days and responding to acetaminophen, are consistent with an acute-phase response that has been reported in patients receiving bisphosphonates, including alendronate sodium.

We also examined interactions between variables.

Cyclical etidronate (Didronel) has fewer upper GI side effects but more lower GI side effects than alendronate.

It is in the 15 November 2011 issue of Annals of Internal Medicine (volume 155, pages 668-679).

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It is likely that calcium supplements, antacids, and some oral medications will interfere with absorption of FOSAMAX.

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Individuals using Fosamax who undergo dental surgery, such as tooth extractions, are more at risk for developing osteonecrosis of the jaw.

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Injury to the bone in these patients via tooth extraction, dental surgery, or mechanical trauma is thought to initiate bisphosphonate-related osteonecrosis of the jaw (BRONJ).

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Some contributing factors include the point of diagnosis, number of involved joints, acuteness of illness, recurrence, response to medication, joint integrity, anatomical involvement and progression of disease.

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While some physicians use bone density scans to help drive their decisions, doctors generally prescribe them to women who are at an increased risk for either osteoporosis or fractures from osteoporosis they already have.

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Until further studies address these important clinical questions, it is important to tell such patients that we currently lack sufficient data from well-controlled clinical trials to determine either benefits or risks assumed with these pharmacological interventions.

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For the treatment of osteoporosis, alendronate sodium tablets increase bone mass and reduce the incidence of fractures, including those of the hip and spine (vertebral compression fractures).

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Associations between the 2007 Medicare reimbursement reduction for bone mineral density testing and osteoporosis drug therapy patterns of female Medicare beneficiaries.

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Bisphosphonates (risedronate and alendronate) also reduced the clinical and radiographic fracture rate in patients receiving glucocorticoids.

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An appreciation of the complex network that leads to these cellular and inflammatory responses will form a foundation on which to develop therapeutic interventions to combat inflammatory periprosthetic bone loss.

There is some literature to recommend waiting 4 hours between taking the levothyroxine and the calcium.

These drugs work to alter the cycle through which bone is formed and broken down within the body.

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Coombes GM, Rogers SR, Porras AG: Elimination and biochemical responses to intravenous alendronate in postmenopausal osteoporosis.

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