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Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: first results of the tREACH trial.

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In 3 large Phase III clinical trials (US301, MN301, and MN302), leflunomide had equivalent clinical efficacy and tolerability to methotrexate and sulfasalazine and superior efficacy and tolerability compared with placebo.

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Consensus statements do not recommend their use until at least one nonbiologic DMARD, usually MTX, has been administered without sufficient success.

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The American College of Rheumatology recommends all persons taking LEF for RA have safety blood tests every 4-12 weeks as long as they continue on LEF.

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Liver biopsies taken before and during methotrexate therapy in 24 patients with psoriasis showed increase in hepatocyte membrane whorls and vacuoles and increase in autophagic vacuoles, but no correlation with duration of therapy or total dose).

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The BDI-II is a questionnaire that consists of 21 multiple choice questions that allow self-reporting of a multitude of depressive symptoms.

Leflunomide is the generic form of the brand-name medicine Arava, which is used to treat rheumatoid arthritis (a condition in which the body attacks its own joints).

Store leflunomide at room temperature at 77 degrees F (25 degrees C).

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It is used to reduce signs and symptoms, inhibit structural damage as evidenced by X-ray erosions and joint space narrowing and improve physical function.

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DMARDs are also called immunosuppressive drugs or slow-acting antirheumatic drugs (SAARDs).

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Successful DMARD therapy may eliminate the need for other anti-inflammatory or analgesic medications; however, until the full action of DMARDs takes effect, anti-inflammatory or analgesic medications may be required as bridging therapy to reduce pain and swelling.

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If you want to become pregnant within the 2 years after treatment be sure to talk to your doctor as there is an option for a treatment that will help to remove this medication more quickly from your body.

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