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Either dronedarone or ranolazine caused a small slowing of AV conduction without causing second-degree AV block (i.
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Pharmacokinetic results are reported in Table 7, below.
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Effects of the antianginal drug, ranolazine, on the brain sodium channel Na V1.
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Treatment of isolated working rat hearts with leptin also increases fatty acid β-oxidation of both exogenously and endogenously derived fatty acids, and is associated with a decrease in intramyocardial TAG stores ().
Testing for Myocardial Ischemia.
Trimetazidine is described as the first anti-ischemic agent developed and marketed by (France).
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The effect of age on clinical outcomes and health status BARI 2D (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes).
Of note, as described previously, verapamil did cause a substantial 32.
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Anti-ischemic therapy included long-acting metoprolol, amlodipine, and isosorbide mononitrate, alone or in combination, together with simvastatin and either lisinopril or losartan for secondary prevention.
In separate atrial preparations, 5 μM of ranolazine was effective in terminating persistent AF only in 1 out of 5 atria (Table 2).
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In addition to metabolic modulation, ranolazine prevents late inward sodium entry.
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The main goals of the present review are to summarize knowledge and discuss mechanisms of ranolazine's effects on both atrial and ventricular arrhythmogenesis.
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The evidence suggests that ranolazine may be an option for intensification of anti-anginal therapy if first-line therapies fail, they noted, a point of agreement with the MERLIN-TIMI 36 trialists.
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Of the 11 enrolled patients, 1 patient reported symptoms of dizziness, leg weakness, and hand tremors; review of her medications revealed that she had been taking darifenacin (a CYP3A4 substrate), a competitive muscarinic receptor antagonist (for the treatment of urinary incontinence), but had forgotten to report this medication during the baseline visit.
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