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No negative influence of SHypo was found after using functional mobility as a marker of health status in this elderly population ().

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Although achieving optimal l-T 4 replacement may seem a rather straightforward task, consistently reaching the target TSH may be rendered problematic due to a variety of factors including the cause and severity of hypothyroidism, sex, age, gender, menstrual status, body weight, lean body mass and body surface area, comorbidities, pathological or physiological conditions, drugs, and adherence to therapy ().

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Some studies have shown adverse effects of high FT 4 values on prognosis, risk of AF, cardiovascular events, dementia, and frailty in elderly patients ().

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An increased dose of l-T 4 is necessary in patients with hypothyroidism treated with l-T 4 who have elevated serum TSH during treatment with sertraline ().

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The dose requirement of l-T 4 also seems to be associated with hormonal status, with lower doses required in postmenopausal women compared with premenopausal women ().

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