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Q: Can Deriphyllin Tablet Be theophylline Given To Patients With Heart Disorders? In cultured human cells, theophylline induced sister chromatid trade and chromosomal breaks but not micronuclei or chromosomal aberrations. It induced sister chromatid exchange and chromosomal aberrations but not micronuclei or gene mutation in animal cells in vitro. Results on the induction of chromosomal aberrations in vegetation are equivocal. Theophylline gave unfavorable leads to the Salmonella/mammalian microsome assay but induced mutation in different micro organism. theophylline In extracts of Escherichia coli, theophylline selectively inhibited some purine nucleoside phosphorylases (Koch