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In conclusion, infliximab monotherapy and combination therapy with infliximab plus azathioprine, as compared with azathioprine alone, resulted in significantly higher rates of corticosteroid-free clinical remission among patients with moderate-to-severe Crohn's disease.

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Mycophenolate mofetil is as efficacious as, but safer than, cyclophosphamide in the treatment of proliferative lupus nephritis: a meta-analysis and meta-regression.

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Dosage adjustment for concomitant use with allopurinol: Reduce azathioprine dose to one-third or one-fourth the usual dose when used concurrently with allopurinol.

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Monitoring for any of these side effects should be considered every 4 to 8 weeks while on therapy.

Three weeks later, serum ALT and alkaline phosphatase levels, which had been normal, began to rise and a week later he became jaundiced (Table).

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The RITUXVAS trial, by The European Vasculitis Study Group (EUVAS), examined the use of rituximab in severe GPA with renal involvement in older patients and found rituximab was not superior to cyclophosphamide and was associated with a similar number of adverse events, although the rituximab group also received cyclophosphamide.

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