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Does CBD help with restless legs? Another study found that Sativex (a sublingual cannabis-based spray that contains CBD and THC) helped 40-50 percent of the RLS patients with their sleeping issues. Fortunately, cannabis and CBD can help treat insomnia, but especially CBD, which often delivers sedative and mellow effects to users.
What medications make restless legs worse? A number of medications can make RLS worse. In particular, anti-nausea drugs and sedating antihistamines (like Benadryl) block the brain's dopamine receptors, causing restless legs symptoms. Antidepressants that increase serotonin and antipsychotic medications can also aggravate the condition.