Turkesterone is swiftly becoming one of the most popular muscle-building supplements that also has fat-burning properties.
While it appears to be becoming increasingly difficult to obtain due to great consumer demand, there is a lot of excitement about this anabolic product.
Many YouTubers and bloggers have spoken extensively about this pill — but is turkesterone worth all of the hype?
What exactly is Turkesterone?
Turkesterone is one of the key bioactive substances naturally present in Marla Root, Leuzea plant, or Ajuga turkestanica – a plant with a long history of use in traditional medicine for its anabolic, adaptogenic, hepatoprotective, and hypoglycemic properties.
With a presence in Central Asia, particularly in Uzbekistan and Tajikistan, the Ajuga turkestanica plant has been the center of attention in recent months as numerous fitness influencers have widely covered this fascinating new anabolic supplement.
Turkesterone is an ecdysteroid, like ecdysterone, that promotes muscle growth but does not bind to the androgen receptor, like anabolic steroids and SARMs do.
"Ecdysteroids are steroid hormones that are produced by arthropods and potentially other invertebrate groups." [R]
And, of all the ecdysteroids, Turkesterone appears to be the most anabolic.
Ecdysterone promotes lean mass gains via estrogen receptor-beta (ER) activation, which is significant because ER signaling regulates skeletal muscle growth and regeneration by stimulating anabolic pathways, activating satellite cells, and modulating immune function, which are pathways that other anabolic compounds do not typically use.
Other Ecdysteroids, such as Ecdysterone, also promote muscle protein synthesis (MPS) via direct or indirect stimulation of the PI3K/Akt signaling pathway, making Ecdysteroids as a class very potential as an exciting anabolic substance as the legality of SARMs is called into question.
According to one study, ER activation can enhance skeletal muscle growth , laying the groundwork for the ER to be responsible for the anabolic impact of Ecdysteroids in addition to stress reduction, which can indirectly boost free testosterone levels.
Another study used an ANTIBETA chemical on myotubes to see skeletal muscle growth from the ER. This provides a possible receptor for Ecdysteroids such as turkesterone.
Following that, the 2 adrenergic receptor has been proposed as a potential vector for Ecdysteroids actions, as this receptor, when stimulated, is capable of producing anabolic effects, comparable to Clenbuterol, which is often used to assist bodybuilders shed fat.
A examination of the structure's homology in relation to the 2 adrenergic receptor revealed a potentially high affinity for the 2 adrenergic receptor. Through the use of Ecdysteroids, this might hypothetically create anabolic effects.
Although no human trials have been conducted to confirm these findings, additional research has used "binding" experiments using 20-hydroxyecdysone on functional activation assays utilizing cAMP. This effectively assessed the binding affinity of the 2 adrenergic receptor for Ecdysteroids.
The subsequent results revealed a complete lack of binding to the receptor, excluding out the 2 adrenergic receptor from consideration.
Instead, the findings suggest that another G protein-coupled receptor (GPCR) could be to blame for the anabolic activity observed in the literature.
The data reveals that the AKT pathway is responsible for the enhanced muscle protein synthesis during Ecdysteroids deployment. When 20-hydroxyecdysone is delivered, the AKP pathway's activity is dramatically boosted. Protein synthesis is also decreased when this route is directly inhibited. However, supplied doses would be several times greater than current cycle recommendations.
A 2020 study showed that the ER route is probably not primarily responsible for anabolic activity, but only when it is activated in conjunction with a GPCR.
The putative culprit was thought to be the MAS receptor, as opposed to the AKT activation revealed in the prior work. The AKT pathway is capable of mediating MAS receptor activation.
The researchers discovered the consequences of AKT pathway activation via the MAS receptors. It should also be mentioned that the AKT and ER pathways are known to be linked, with studies demonstrating that their mutual activation influences one another under specific conditions.
Although this is only half of the story, our data suggests that other unknown GPCRs may still play a significant role in the activation of both the ER and PLC-IP3 pathways, leading to calcium flux channels that activate the AKT pathway and the resultant anabolic activity.
Despite the processes of Turkesterone and other Ecdysteroids, it must be mentioned that Ecdysteroids have no androgenic effects and no affinity for the Androgen receptor, which is why its side-effect profile is modest and no PCT is necessary. However, it must be acknowledged that its efficacy may be overestimated and/or overhyped.
Turkesterone also works by 'hacking' the body's stress response. This is accomplished by maintaining a constant equilibrium in the adrenal, pituitary, and hypothalamus glands. These three glands each produce hormones that help regulate our blood pressure, immune system, mood, vision, growth, and other functions, all of which contribute to the creation of favorable conditions for muscle growth, among other benefits.
One of the most appealing advantages of Turkesterone is the lack of adverse effects or the requirement for post-cycle therapy (PCT).
Turkesterone can help users gain muscle and power while decreasing body fat.
Although some reviewers praise turkesterone, a placebo effect must be considered.
In our chapter on other benefits, we will also detail Turkesterone's other stated health benefits.
What Do Turkesterone Studies Reveal?
Many of the findings that are pushed online should be taken with caution. Some research have incorrectly claimed that Turkesterone is more potent than Dianabol, which it is not.
Turkesterone and Ecdysteroids have an anabolic effect.
Ecdysteroids and Turkesterone have been shown in animal tests to have a considerable anabolic impact, enhancing lean muscle mass and strength. However, one important takeaway from those research is that none were conducted on humans. Over 10 weeks, one study on strength trained individuals using ecdysterone from spinach extract at 200mg and another group at 800mg p/day dosage demonstrated significant muscular hypertrophy and strength increases over control, with the 800mg group outperforming the control group in all parameters.
"The 800mg group gained an average of 3.2kg (7lb) of muscle mass compared to the control group, which exhibited a little loss or rise in muscle mass over the 10 weeks."
However, another study that used 20-hydroxyecdysone at 200mg for 8 weeks found no difference in any strength metric when compared to the control.  I'm not sure why these trials produced such disparities in findings; the quality of the substance could be a problem, or perhaps the 20-hydroxyecdysone does not perform as effectively in people as it does in rodent and other animal models."
endurance and strength
Some studies examined their athletes' strength measures, and 20-hydroxyecdysone had no discernible effects on any given strength parameter.
However, another study found that "during the ten weeks, the 800mg group boosted their Squat by nearly 20% and their bench press by 10%."
Because the findings of both trials are so conflicting, it's difficult to say whether Ecdysteroids have a discernible anabolic impact.
Some influences like Ecdysterone over Turkesterone, and vice versa.
Rodent-based models measure both swimming time and grip strength, and the results show that supplementing with Ecdysteroids at relative dosages significantly greater than any existing recommendations for people results in a dose-dependent improvement in strength and endurance.
Despite encouraging outcomes in rodent-based models, more clinical studies with human test subjects would be required to get a proper response, given the inconsistent results.
This new workout supplement appears to have a few health benefits with a low side effect profile.
Aside from its muscle-building characteristics, Turkesterone has a few other advantages that are unrelated to bodybuilding:
improve gut health, improve endurance, lower cholesterol, manage blood pressure, improve insulin sensitivity, improve neurotransmitter activity, and improve liver health.
antiproliferant, antibacterial, effective in promoting healing, and capable of lowering hyperglycemia
It should be noted that human studies on turkesterone Australia are currently quite scarce.
SARMs vs. Turkesterone
Over SARMs, Turkesterone appears to be a safer option for lifters looking to push their training to the next level.
SARMs can lower testosterone levels and cause a variety of adverse effects, including:
Turkesterone, like other ecdysteroids, does not suppress natural testosterone synthesis, does not require a PCT, and can help stabilize blood pressure, enhance lipid profiles, and improve liver function.
Dosages of Turkesterone How long should I keep Turkesterone running?
Because research on Turkesterone is scarce, the most widely acknowledged cycle appears to be 500mg per day for 8-12 week cycles, though some users have been known to run cycles with doses as high as 2000mg per day.
There is no requirement for a PCT because it is not suppressive.
Turkesterone legality - Will I still be "natural"?
If you start using this vitamin, you will still be "natural." Turkesterone has been added to WADA's PED watchlist, which might indicate that its legality could change on a dime.
"These findings [on ecdysteroids] present novel therapeutic perspectives for the treatment of muscle injuries, sarcopenia, and cachectic illness, but also imply that such a medication could be abused for doping purposes," according to one study.
Earlier this year, we discussed how the FDA targeted NAC as a supplement, causing Amazon to remove the item from their online storefronts.
There is no chance of this product being shut down because it does not attach to the androgen receptor, imitating the effects of endogenous natural testosterone synthesis.
Yes, a supplement that promises supraphysiological outcomes may raise eyebrows among die-hard natural lifters, but Creatine — one of the most extensively used and safest supplements on the market — can also help you gain supraphysiological strength and size.
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