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The report shows that the drug produced few significant side effects.
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As always, treatment decisions are between you and your doctor.
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Cytogenetic improvement has been observed in 70% of patients treated for longer than 3 months, with the median of Ph1-positive cells declining from 100% to 65% (range 0-95%).
About 45% of patients were women and 6% were black.
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It may also be used to prevent cancer from growing in patients after surgical removal of GIST.
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The most frequent adverse effects were nausea (in 55 percent of patients), vomiting (41 percent), and edema (41 percent); most of these were grade 1 (mild) or grade 2 (moderate).
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However, it has been found that patients with exon 9 mutations may require a higher dose of imatinib.
OUTLINE: This is a phase I, dose-escalation study followed by a phase II and a pilot study.
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