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Other common side effects include joint pain, weakness, numbness and rash.
In 2010, PDMA approved a biosimilar epoetin, although its indication does not include oncology; no oncology biosimilar has yet received PDMA approval.
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Although not proof of rHuEpo doping, testing for haematocrit or Hb levels above a certain value has been explored.
The institute will focus on three immunotherapy areas: stimulating the patient's T-cells, boosting the response rate to current drugs and researching alternative methods of attacking tumors.
Low dose erythropoietin in maintenance haemodialysis: improvement in quality of life and reduction in true cost of haemodialysis.
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One study estimates that between 2007 to 2020, biosimilars will have saved between Euros 11.
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Biosimilar Rituximab: First to Market in the EU?
Marketing Authorisation Application for its proposed biosimilar of Amgen's ( - ) Neulasta (pegfilgrastim) in the EU.
Tribunale amministrativo regionale (TAR) del Lazio and referred five legal questions to the European Court of Justice (ECJ) for a preliminary ruling.
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The FDA has issued four draft biosimilar guidances from 2010 to 2014.
G-CSF), accounting for about half of the global regulated market.
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However, all syringes remained within the 80 to 125% of the stated dose allowed with the European Pharmacopoeia monograph for erythropoietin.
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Zarxio, a biosimilar version of Amgen Inc.
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Celltrion developed a biosimilar infliximab and splits global marketing rights to the product with Hospira, each commercializing the product in different regions.
CONCLUSIONS: Patients with intertrochanteric fractures seem to benefit from the use of epoetin alfa because it is safe and reduces the need for blood transfusions.
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When NICE recommends a treatment 'as an option', the NHS must make sure it is available within the period set out in the paragraph above.
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However, in the USA, there are many regulatory and legal obstacles to widespread use of biosimilars.
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Recombinant human erythropoietin in anemic patients with end-stage renal disease.
These differences have no effect on the medical action of the drug whatsoever.
The quality items assessed included allocation concealment, blinding of participants, investigators and outcome assessors, intention-to-treat analysis, and the completeness of follow-up.
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