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How often should you take cephalexin 500mg? The usual dose of oral KEFLEX is 250 mg every 6 hours, but a dose of 500 mg every 12 hours may be administered. Treatment is administered for 7 to 14 days. For more severe infections larger doses of oral KEFLEX may be needed, up to 4 grams daily in two to four equally divided doses.
How do you take antibiotics 4 times a day? When to take it Try to space the doses evenly throughout the day. If you take phenoxymethylpenicillin 4 times a day, this could be first thing in the morning, around midday, late afternoon and at bedtime. If you're taking it twice a day, leave 12 hours between each dose.