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Following the issuance of a number of warnings by the FDA since 2010 that connected Actos usage for at least 12 months with complications such as bladder cancer by increasing the risks of contracting it to more than 40 %, hundreds of lawsuits have been filed against Takeda Pharmaceuticals.

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The FDA cleared Actos of a heart attack link rather quickly, though some European countries pulled it from the market.

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Because hyperglycemia plays a central role in the microvascular and macrovascular complications of diabetes, it is possible that interventions that prevent or delay hyperglycemia may effectively prevent or delay these long-term complications.

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The first five years of a 10-year follow-up study in humans showed an increased risk of bladder cancer in those patients who take pioglitazone for an extended time.

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Actos is manufactured by the Takeda Pharmaceuticals and has been discovered to have a number of previously unknown side effects, which the company had previously not disclosed.

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The half-way findings of this 10-year study were submitted to the FDA in 2010 against which the US governmental agency came out with a Drug Safety Communication.

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According to a court documents, the collaboration ended due to Upjohn Management concerns about litigation over Actos and “concerns about some of the results from longer term toxicity studies on pioglitazone.

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There have been postmarketing reports of fatal and non-fatal hepatic failure in patients taking Actos, although the reports contain insufficient information necessary to establish the probable cause.

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Taking pioglitazone, along with adopting a healthy lifestyle, can decrease your risk of developing the serious or life-threatening complications of type 2 diabetes.

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Actos is used for type 2 diabetes, not type 1 diabetes or diabetic ketoacidosis.

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training.

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