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Because RA is a chronic disease, you may need to take LEF for years.
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Rate the appropriateness of initiating TNFα inhibitor in a patient with a history of arthritis of 5 or more joints who has received methotrexate for 6 months and has moderate disease activity and features of poor prognosis”).
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In a systematic review and meta-analysis reporting on the risk of malignancy in patients with RA treated with TNF inhibitors, the data reviewed showed that these agents did not increase the risk of malignancy, particularly lymphoma; however, they did appear to increase the risk of skin cancer, including melanoma.
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