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Primary disease presents with one or more painless ulcers or chancres at the inoculation site.

Nearly half (42%) of these prescriptions were for conditions not approved by the FDA, such as acute bronchitis, otitis media, and acute upper respiratory tract infection, according to a study that was supported in part by the Agency for Healthcare Research and Quality.

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Cegielski suggested that the high level and diversity of drug resistance found at baseline suggests that standardized treatment approaches for MDR TB are not advisable.

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