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Key area - Systemic toxicity. Woirkshop on Alternative Methods - Ankara, 12-13 November 2007. 5. Acute oral toxicity - OECD test guidelines. Deletion of TG 4018 May 2013 OECD 420 / 423 / 425 GUIDELINES- authorSTREAM Presentation. In 1984, a new approach - acute toxicity testing was suggested by the 11 Mar 2008 This revised Toxicity Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following 17 Apr 2018 Three alternative test methods (Guidelines 420, 423,and 425) to the traditional acute oral toxicity test have been adopted by the OECD. One of 17 Dec 2001 OECD Guidelines for the Testing of Chemicals are periodically reviewed found in the Guidance Document on Acute Oral Toxicity Testing (8). 17 Dec 2001 OECD guidelines for the Testing of Chemicals are periodically reviewed in the light in the Guidance Document on Oral Toxicity Testing (12). Guidelines (TGs 402, 403, 420, 423, and 425) describe acute systemic testing. Fixed Dose Procedure (OECD TG 420). Acute Toxic Class method (OECD TG 17 Dec 2001 OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. This procedure is reproducible, uses very few animals and is able to rank substances in a similar manner to the other acute toxicity testing methods (Test Guidelines 420 and 425). VMG-mammalian. Validation Management Group for mammalian toxicity tests. WNT Working Group of National Co-ordinators of the Test Guidelines Programme. 1 Mar 2017 401,420,423,425) OECD GUIDELINES FOR CARCINOGENICITY (451) (Principle ACUTE ORAL TOXICITY Test Guidelines No. 40 1 423