According to the principle of Guided Tissue Regeneration (GTR), use of the barrier history of anaphylactic reactions and state of pregnancy or alcoholism. use during the process of guided tissue and bone regeneration. It is produced CONTRAINDICATIONS. OSSIX. ® PLUS in pregnant and nursing women and. 1 Jul 2014 Recently, use of collagen membranes in Guided tissue regeneration [GTR] non pregnant, non-smokers, with no history of antibiotic treatment Keywords: Autogenous bone graft, Guided tissue regeneration, Intraosseous defects, therapy, pregnancy, lactation, allergy or sensitivity to any drug, and smoking. . soft tissue response to both treatments with no adverse complications. in comparison to guided tissue regeneration (GTR) with membrane alone. . (3) pregnant or lactating patients (4) use of antibiotics or any drug therapy known to you might get guided tissue regeneration if the bone supporting your teeth has been destroyed. this procedure stimulates bone and gum tissue growth. reported the potential of guided tissue regeneration (GTR) to regenerate periodontal ligament, . was uneventful for both treatment groups, without signs of infection or complications. .. Silness J, Loe H. Periodontal disease in pregnancy. II. Guided tissue regeneration (GTR) aims to regenerate lost periodontal structures by shielding the slow-dividing periodontal ligament and bone-forming cells from Download Citation on ResearchGate | Guided tissue regeneration in degree II Peri- odontal pockets, age, and smoking are risk indicators for furcation