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In the patients with YMDD mutations, HBV DNA and alanine aminotransferase levels did begin to rise but did not reach base-line levels by week 52.

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The doses used in the teratology studies resulted in peak zidovudine plasma concentrations (after one-half of the daily dose) in rats 66 to 226 times, and in rabbits 12 to 87 times, mean steady-state peak human plasma concentrations (after one-sixth of the daily dose) achieved with the recommended daily dose (100 mg every 4 hours).

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