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The pregabalin and lorazepam groups experienced greater reductions in Hamilton Anxiety Rating Scale (HAM-A) score by week 4 compared with placebo, with no observed statistically significant differences among the active-treatment groups.

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In the 8-week placebo-controlled bipolar depression study in adults, the most commonly observed adverse reactions associated with the use of Quetiapine (incidence of 5% or greater) and observed at a rate on Quetiapine at least twice that of placebo were (52%), (37%), increased appetite (12%), (7%), (7%), and (6%).

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However, there is not enough data on the safety of quetiapine, more commonly called Seroquel, during pregnancy.

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Short-term studies suggested that patients treated with quetiapine monotherapy were significantly more likely than patients treated with placebo and further active comparators to achieve higher response and remission rates as well as more clinical improvements at the endpoint.

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Extrapyramidal symptoms (EPS) occurred across quetiapine and placebo groups, but there were no significant differences between quetiapine and placebo recipients on objective measures of EPS and akathisia.

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In the 6-week placebo-controlled fixed dose adjunctive therapy clinical trials, for MDD, the most commonly observed adverse reactions associated with the use of Quetiapine (incidence of 5% or greater and observed at a rate on Quetiapine and at least twice that of placebo) were (150 mg: 37%; 300 mg: 43%), (150 mg: 27%; 300 mg: 40%), (150 mg: 14%; 300 mg: 11%), 300 mg only: 11%) and weight increased (300 mg only: 5%).

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The antidepressant effects of quetiapine are poorly understood, but may be related to antagonism of 5-HT2A receptors in cortical regions, partial agonism of 5-HT1A in the prefrontal cortex in association with increased extracellular dopamine release in the region, or to reduced synaptic reuptake of noradrenaline resulting from inhibition of the noradrenaline reuptake transporter by the quetiapine metabolite norquetiapine.

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