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Quetiapine was titrated gradually based on tolerability and effect during the first 3 weeks up to a maximum total daily dose of 300 mg (100 mg qam and 200 mg qhs).

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The pregabalin and lorazepam groups experienced greater reductions in Hamilton Anxiety Rating Scale (HAM-A) score by week 4 compared with placebo, with no observed statistically significant differences among the active-treatment groups.

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Atalay A, Turhan N, Aki OE "A challenging case of syndrome of inappropriate secretion of antidiuretic hormone in an elderly patient secondary to quetiapine.

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The purpose of this study was to determine if there were any changes in problem behavior associated with discontinuation of quetiapine for an individual diagnosed with severe intellectual disability using functional analysis methodology.

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In general, there was no indication of any different tolerability of quetiapine fumarate in the elderly compared to younger adults.

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In the 8-week placebo-controlled bipolar depression study in adults, the most commonly observed adverse reactions associated with the use of Quetiapine (incidence of 5% or greater) and observed at a rate on Quetiapine at least twice that of placebo were (52%), (37%), increased appetite (12%), (7%), (7%), and (6%).

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However, there is not enough data on the safety of quetiapine, more commonly called Seroquel, during pregnancy.

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Pharmacokinetic studies have shown that, when given in equivalent daily doses, the exposure in terms of area under the curve (AUC) of the two compounds is comparable.

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Results of clinical trials and observations in case studies have revealed possible beneficial effects of quetiapine on several subjective and objective sleep parameters.

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Short-term studies suggested that patients treated with quetiapine monotherapy were significantly more likely than patients treated with placebo and further active comparators to achieve higher response and remission rates as well as more clinical improvements at the endpoint.

Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy with quetiapine.

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Extrapyramidal symptoms (EPS) occurred across quetiapine and placebo groups, but there were no significant differences between quetiapine and placebo recipients on objective measures of EPS and akathisia.

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Effectiveness data were available for 327 patients treated with RLAI and 326 with quetiapine.

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Community studies of persons with sub-diagnostic anxiety symptoms over time often show episodic symptoms and prolonged periods of remission, with symptoms reappearing or worsening during adverse life events and psychosocial stressors.

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The radioactivity from each PET measurement was reconstructed in a series of time-frames consisting of four 15-s, four 30-s, six 1-min, six 3-min and six 6-min frames.

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This 10-day, single-center, open-label, randomized, crossover study compared pharmacokinetic profiles and tolerability of extended release quetiapine fumarate (quetiapine XR) with quetiapine immediate release (quetiapine IR) in patients with schizophrenia, schizoaffective disorder or bipolar disorder.

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In summary, data from this study support earlier studies showing good relapse prevention in stable patients with schizophrenia or schizoaffective disorder switched to treatment with RLAI.

In the 6-week placebo-controlled fixed dose adjunctive therapy clinical trials, for MDD, the most commonly observed adverse reactions associated with the use of Quetiapine (incidence of 5% or greater and observed at a rate on Quetiapine and at least twice that of placebo) were (150 mg: 37%; 300 mg: 43%), (150 mg: 27%; 300 mg: 40%), (150 mg: 14%; 300 mg: 11%), 300 mg only: 11%) and weight increased (300 mg only: 5%).

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One surprise for the researchers was that 24% of lithium patients and 27% of quetiapine patients required no other medications and improved on monotherapy.

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The antidepressant effects of quetiapine are poorly understood, but may be related to antagonism of 5-HT2A receptors in cortical regions, partial agonism of 5-HT1A in the prefrontal cortex in association with increased extracellular dopamine release in the region, or to reduced synaptic reuptake of noradrenaline resulting from inhibition of the noradrenaline reuptake transporter by the quetiapine metabolite norquetiapine.

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Lithium: Concomitant administration of quetiapine (250 mg tid) with lithium had no effect on any of the steady-state pharmacokinetic parameters of lithium.

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