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The primary efficacy endpoint was the change in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score from baseline to week 4 post-injection.

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The authors concluded that the use of BTX type A may be an important adjunctive therapy to increase the therapeutic effect of baclofen on spasticity in small muscles, resulting in a more focal effect, and improving the use of orthoses and the effectiveness of rehabilitation programs in patients after SCI.

The potency units of incobotulinumtoxinA are not interchangeable with other preparations of botulinum toxin products.

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The investigators reported a significant difference in treatment response (as determined by participant assessment) between the subjects injected with rimabotulinumtoxinB and placebo.

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Spasms and reduced flow to the may occur along with the rise in pressure, causing fissures or keeping existing fissures from healing.

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Results from the present study supported the efficacy of botulinum toxin A to reduce myofascial pain symptoms in bruxers, and provided pilot data which need to be confirmed by further research using larger samples.

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Furthermore, an UpToDate review on “Chronic exertional compartment syndrome” (Meehan, 2014) does not mention the use of botulinum toxin as a therapeutic option.

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