Cocaine is addictive because of its result on the reward pathway inside the brain. when a short period of use, there's a high risk that dependence can occur. Its use also will increase the risk of stroke, myocardial infarction, lung issues in those that smoke it, blood infections, and sudden cardiac death.

cocaine sold on the road is commonly mixed with local anesthetics, cornstarch, quinine, or sugar, which may result in additional toxicity. Following repeated doses, a person may have decreased the ability to feel pleasure and be very physically tired.
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