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It is effective in some patients for treatment of acute attack of migraine but has no role in migraine prophylaxis.

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The substance responsible for the traditional clinical effect of ergot".

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It has 8 subforms: medication overuse headache induced by ergotamine, triptans, analgesics (simple and combined), opioids, undefined multiple drug classes, and others.

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Ergot alkaloids have multiple side effects, but have little effect on the liver and have not been clearly linked to instances of clinically apparent acute liver injury.

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Corrected online 03 April 2015 In the section discussing treatment options during pregnancy, subheadings 'Ergot alkaloids' and 'Antidepressants' should cite reference 25, not 23.

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This approval, in 1996, was based on the results of the National Institutes of Neurologic Disorders and Stroke (NINDS) study which showed that patients who received IV-tPA after fulfilling certain criteria have significantly better outcomes than those who did not.

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Moreover, like the ergot alkaloids, in certain formulations some analogues of these macrolides can be called drugs.

Among all the conditions studied, the frequency of use of unconventional therapy was highest for back problems (36 percent), anxiety (28 percent), headaches (27 percent), chronic pain (26 percent), and cancer or tumors (24 percent).

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They cause a wide range of gastrointestinal, dermatological, and neurologic symptoms; see Trenholm et al.

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An alkaloid from ergot, used to relieve migraine; it is a potent stimulant of smooth muscle, particularly of the blood vessels and the uterus, and produces adrenergic blockade (chiefly of the alpha receptors); hydrogenated ergotamine, dihydroergotamine, is less toxic and has fewer side effects.

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There are few reports of ergotism among patients taking doses within the recommended limits or for brief periods of time.

Protease inhibitors (ritonavir, amprenavir, atazanavir, indinavir, nelfinavir, and saquinavir) increase blood levels of ergot alkaloids by inhibiting CYP3A4 metabolism, acute ergot toxicity has been reported; concomitant use is contraindicated.

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