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Why is neostigmine preferred over physostigmine? Unlike physostigmine, neostigmine has a quaternary nitrogen; hence, it is more polar and does not cross the blood–brain barrier and enter the CNS, but it does cross the placenta. Its effect on skeletal muscle is greater than that of physostigmine. Neostigmine has moderate duration of action – usually two to four hours.
Is tensilon an anticholinergic? PHARMACOLOGIC TESTING The edrophonium (i.e., Tensilon) test is useful in diagnosing myasthenia gravis. Anticholinergic side effects of edrophonium include bradycardia, nausea, vomiting, increased tearing, and lacrimation.
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