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Most physicians are aware of the use of liver function tests to detect hepatotoxicity in patients with tuberculosis who are being treated with isoniazid (INH; Laniazid, Nydrazid).
The reappearance of liver injury with reexposure or rechallenge is perhaps the most convincing evidence for a medication being the cause of the hepatotoxicity.
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Thus, it appears that both tuberculosis and HIV can be treated successfully with concurrent use of a rifabutin-based regimen and potent combinations of antiretroviral agents.
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The 1994 US CDC guidelines for tuberculosis erroneously cite Slutkin as evidence that a nine-month regimen using only isoniazid and rifampicin is acceptable, but almost all of the patients in that study received ethambutol for the first two to three months (although this is not obvious from the abstract of that article).
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