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Because these studies were retrospective, they established only an association and not a causal relationship between concomitant use of clopidogrel and PPI and adverse clinical outcomes.
Ninety-two percent (92%) of the patients in the CURE study received heparin or low molecular weight heparin (LMWH), and the rate of bleeding in these patients was similar to the overall results.
Indeed, taken as a whole they indicate the converse, although direct evidence from further randomised trials of antiplatelet therapy among diabetic patients would still be helpful.
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The risk of major bleeding was low and was similar in the two study groups, but the prasugrel dose was adjusted for patients who were 75 years of age or older and for those weighing less than 60 kg in order to mitigate such risks.
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Intracoronary compared to intravenous abciximab and high-dose bolus compared to standard dose in patients with ST-segment elevation myocardial infarction undergoing transradial primary percutaneous coronary intervention: a two-by-two factorial placebo-controlled randomized study.
VTE, but its efficacy to prevent ATE is also not established, and the biological plausibility to support its efficacy for this therapeutic aim may be questioned.
Prasugrel but not high dose clopidogrel overcomes the lansoprazole neutralizing effect of P2Y12 inhibition: Results of the randomized DOSAPI study.
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The concordance between drug dispensing and drug consumption is probably high, because reimbursement of drug expenses is only partial, and most drugs, including PPIs, were not available over the counter in Denmark during the study period (exceptions include aspirin and H 2-antagonists).
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