The Mexican Open is an ATP 500 event played in Acapulco. The city has hosted the men's tournament since its shift from Mexico City in 2001.
The tournament was played on outdoor claycourts up until 2013, but was changed to hardcourts to serve as the lead-up to the North American Masters 1000 events in Indian Wells and Miami.
Second seed and defending champion Zverev also has a tricky first-round opponent in the form of American Jenson Brooksby.
Zverev's projected quarter-final opponent, Cameron Norrie, finds himself in a similarly precarious spot, locked in a first-round tussle against Carlos Alcaraz.
Tsitsipas and Pablo Carreno Busta, the other seeds in the bottom half, have relatively simple paths leading up to the last eight.
The Mexican Open will take place between February 21-26, with the draw featuring 32 players.
The tournament will take place at the Hotel Princess Mundo Imperial in Acapulco, Mexico.
ACAPULCO, Mexico (AP) — Defending champion Alexander Zverev outlasted Jenson Brooksby 3-6, 7-6 (10), 6-2 at the Mexican Open in a first-round match that ended at 4:55 a.m. — the latest-ever finish to an ATP match.
Tuesday morning’s finish broke the record set at the 2008 Australian Open, when Lleyton Hewitt defeated Marcos Baghdatis in a match that ended at 4:34 a.m.
“Right now, I’m just happy to have won,” the third-ranked Zverev said. “I don’t know how Jenson feels. Must be difficult but happy to be a part of history. It was an incredible battle.”
Zverev’s victory in 3 hours, 22 minutes also set a record for the longest match in the 29-year-old history of the hard-court outdoor tournament in Acapulco, a popular beach resort.
It was an odd first day at the Arena GNP because the previous two tournament records for longest match were set earlier, when Stefan Kozlov defeated Grigor Dimitrov 7-6 (8), 5-7, 6-3 in 3 hours, 21 minutes after John Isner beat Fernando Verdasco 7-5, 6-7 (4), 7-6 (3) in 3 hours, 13 minutes.
Matches started at 6 p.m. due to the intense heat during the day in Acapulco.
The second-seeded Zverev will play Peter Gojowczyk in the second round.
Top seed Medvedev faces a tricky first-round opponent in the form of the mercurial Benoit Paire. The path gets slightly easier for the Russian after that, with a potential quarterfinal against Taylor Frtiz or Adrian Mannarino looming.
2020 champion Rafael Nadal, meanwhile, finds himself in a tricky part of the draw. He opens against Reilly Opelka, who is scheduled to play in the Delray Beach final on Sunday, with familiar foe Grigor Dimitrov lying in wait in the second round.
Fifth seed Matteo Berrettini is Nadal's potential quarter-final opponent, but the Italian will first need to find his way past the likes of Tommy Paul and Sebastian Korda in the early rounds.