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Either dronedarone or ranolazine caused a small slowing of AV conduction without causing second-degree AV block (i.

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Pharmacokinetic results are reported in Table 7, below.

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Effects of the antianginal drug, ranolazine, on the brain sodium channel Na V1.

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Treatment of isolated working rat hearts with leptin also increases fatty acid β-oxidation of both exogenously and endogenously derived fatty acids, and is associated with a decrease in intramyocardial TAG stores ().

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Anti-ischemic therapy included long-acting metoprolol, amlodipine, and isosorbide mononitrate, alone or in combination, together with simvastatin and either lisinopril or losartan for secondary prevention.

In separate atrial preparations, 5 μM of ranolazine was effective in terminating persistent AF only in 1 out of 5 atria (Table 2).

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The main goals of the present review are to summarize knowledge and discuss mechanisms of ranolazine's effects on both atrial and ventricular arrhythmogenesis.

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