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Due to my peripheral vascular disease I have been unable to walk long distances for more than three years now. But recently my condition got worse. I couldn't walk 500 meters without stopping for a while as I was in pain. This frightened me a lot as I thought soon I could get completely paralyzed and there will be no way out. I know that people like me who are used to be active when they suddenly get deprived from their habitual way of life soon burn down because of deep depression. I knew I wouldn't stand being motionless. And besides that could also mean a quicker end, as my blood would get thicker and that could damage my heart one day. So I gathered all my courage and asked my doctor for another solution. He put me on Pletal and this medication gave me back my life and energy. With the help of this drug I can walk 1 or even 2 miles without feeling any pain or discomfort. That can hardly be called jogging of course, but anyway it's better that lying still and watching the ceiling fall down and smash your life. I do hope that with the help of Pletal I will be able to stay active for long years as I am absolutely happy with the way this medication works and I haven't noticed any negative sides when being on it. I am not a pharmacist and I can not explain how this drug works but it is perfect for its purpose and it helps hopeless people like me get back their guiding light.

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Due to my peripheral vascular disease I have been unable to walk long distances for more than three years now. But recently my condition got worse. I couldn't walk 500 meters without stopping for a while as I was in pain. This frightened me a lot as I thought soon I could get completely paralyzed and there will be no way out. I know that people like me who are used to be active when they suddenly get deprived from their habitual way of life soon burn down because of deep depression. I knew I wouldn't stand being motionless. And besides that could also mean a quicker end, as my blood would get thicker and that could damage my heart one day. So I gathered all my courage and asked my doctor for another solution. He put me on Pletal and this medication gave me back my life and energy. With the help of this drug I can walk 1 or even 2 miles without feeling any pain or discomfort. That can hardly be called jogging of course, but anyway it's better that lying still and watching the ceiling fall down and smash your life. I do hope that with the help of Pletal I will be able to stay active for long years as I am absolutely happy with the way this medication works and I haven't noticed any negative sides when being on it. I am not a pharmacist and I can not explain how this drug works but it is perfect for its purpose and it helps hopeless people like me get back their guiding light.

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The end result is that people do not clot as easily and this effect is mainly seen in the arteries.

We strongly urge you to reject the application for approval of cilostazol (Pletal), a drug to treat intermittent claudication, a chronic, non-life-threatening condition for which there are alternative solutions, including exercise, that do not involve the multitude of known and potentially life-threatening risks that exist with cilostazol.

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If you have any special needs please notify the staff prior to your procedure (pacemaker, internal defibrillator, latex allergy, need interpreter).

On August 6, 2013, the committee will discuss new drug application (NDA) 204819, proposed trade name ADEMPAS (riociguat coated tablet), submitted by Bayer HealthCare Pharmaceuticals Inc.

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There are several others, including Aggrenox (aspirin and dipyridamole), Effient (prasugrel), Ticlid (ticlopidine), and Pletal (cilostazol).

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Short-term (less than or equal to 4 days) coadministration of aspirin with Pletal increased the inhibition of arachidonic acid-induced ex vivo platelet aggregation by 20% compared to Pletal alone and by 48% compared to aspirin alone.

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Administration of ketoconazole 400 mg with cilostazol 100 mg resulted in a 94% increase in the C max and a 117% increase in the AUC of cilostazol.

We compared the effectiveness and harms of clopidogrel, ticlopidine, extended-release dipyridamole and aspirin and prasugrel in adults with acute coronary syndromes or coronary revascularization (stenting, bypass grafting), ischemic stroke or transient ischemic attack, or symptomatic peripheral vascular disease.

Quitting smoking can often reduce the symptoms of PVD and lower your chance that the disease will get worse.

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Less commonly, another surgical procedure called a bypass may be recommended to open larger areas of narrowed arteries.

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A generic drug simply means that the drug is not made by the original manufacturer, the chemical is exactly the same.

Next, the doctor will use an X-ray machine (fluoroscope) to guide the needles into the correct spots.

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Grapes, including the fruit, leaves and seeds, have been used medicinally since the time of the ancient Greeks.

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Cilostazol and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase activity and suppressing cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.

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The right heel also progressed to complete closure with application of Dermagraft combined with other conservative dressing techniques to control for infection through use of topical antimicrobials (silver alginates, Iodosorb gel), exudate management (foam and composite dressings) and edema reduction with light compression wraps.

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The dose regimen in the studies was Omeprazole Delayed-Release Capsules 20 mg twice daily plus clarithromycin 500 mg twice daily plus amoxicillin 1 g twice daily for 10 days; or clarithromycin 500 mg twice daily plus amoxicillin 1 g twice daily for 10 days.

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In these reports cilostazol was used "off label" due to its positive chronotropic action.

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