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I have used 0.75 patch for 6 years. To make it stick better, rub your skin with alcohol and let dry. Press on for ~20-30 secs. Really the only thing I find frustrating is the fact that by the 5th day my body is clearly not getting as much medicine, and I start having body symptoms to parallel this. Also have very sore knots in my breasts, especially the first few days. But other than this, it has been a life-saver since I have post surgical menopause.
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