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There have been reports of patients recovering from nortriptyline overdoses of up to 525 mg.
Is doxepin a histamine?
Lower dose doxepin has a very high selectivity for H1 receptor. It binds with histamine receptors for 100 times more than that of nor-epinephrine and serotonin receptors. Antagonism of histamine receptors in TMN nucleus inhibits the arousal pathway. This produces hypnotic action.
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