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In July 2002, the 15-year long Women's Health Initiative (WHI) abruptly ended its combination of estrogen and progestin therapy study, three years ahead of schedule, when their data revealed higher rates of breast cancer, heart attacks, strokes, and blood clots in the population taking the hormones, compared to those receiving a placebo.

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This is the sort of spinning of science that makes individual points that are true and weaves them into a misleading argument that, because biology is complicated and there is variability in response to a medical intervention, we might as well throw up our hands and do nothing until we find out how to quantify exactly how each individual will react to any given intervention.

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Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women: results from a randomized placebo-controlled study".

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Female sex hormones. Citing his own research, along with a 1954 animal study that found that female estrogens, but not male androgens, were correlated to cavity rates, he said the cumulative effect of estrogens, including fluctuations at puberty and high levels during pregnancy, promote cavities and dietary changes.

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More information: Journal of the American Medical Association 2018.

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Although estradiol can be used in treatment plans for certain types of cancer, long-term use of estradiol medications may result in an increased risk of breast cancer, ovarian cancer or uterine cancer.

The purpose of this article is not necessarily to compare and contrast synthetic from bioidentical HRT; but to alert you as to how the body responds when bioidentical (and synthetic) hormones are taken.

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