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The treatment, known as whole-body hyperthermia, essentially gives patients a mild, transient fever, the researchers explained.

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The neurotransmitters affected are serotonin (5-hydroxytryptamine) and norepinephrine (noradrenaline).

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Arroll B, Elley CR, Fishman T, Goodyear-Smith FA, Kenealy T, Blashki G, Kerse N, Macgillivray S (2009).

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Long-term venlafaxine and milnacipran use suppressed long-term potentiation in hippocampal CA1 via 5-HT1A receptor and a1-adrenoceptor activity, contributing to reversal in synaptic plasticity-related impairment induced by conditioned fear stress.

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Vortioxetine (Brintellix) was approved by the US Food and Drug Administration (US FDA) in September 2013 to treat major depressive disorder (MDD) in adults.

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Similar to venlafaxine, Desvenlafaxine Succinate inhibits the neuronal uptake of serotonin and norepinephrine.

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