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As will be recognized by those skilled in the art, the amount or percentage of the active agent present in the composition and dosage forms will vary.

Therefore, when considering the spatial extension of rCBF decreases, parietal cortex, involving multiple areas, appeared to be more extensively affected in the Huntington's disease group.

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As a result, also provided are pharmaceutical compositions comprising at least one chemical entity described herein and one or more additional pharmaceutical agents used in the treatment of Huntington's disease such as, but not limited to, Amitriptyline, Imipramine, Despiramine, Nortriptyline, Paroxetine, Fluoxetine, Setraline, Terabenazine, Haloperidol, Chloropromazine, Thioridazine, Sulpride, Quetiapine, Clozapine, and Risperidone.

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Similarly, our general conclusions are not affected by changes in the values of K a or K ds within a plausibly physiological range.

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