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Cytogenetic improvement has been observed in 70% of patients treated for longer than 3 months, with the median of Ph1-positive cells declining from 100% to 65% (range 0-95%).

About 45% of patients were women and 6% were black.

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It may also be used to prevent cancer from growing in patients after surgical removal of GIST.

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The most frequent adverse effects were nausea (in 55 percent of patients), vomiting (41 percent), and edema (41 percent); most of these were grade 1 (mild) or grade 2 (moderate).

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However, it has been found that patients with exon 9 mutations may require a higher dose of imatinib.

OUTLINE: This is a phase I, dose-escalation study followed by a phase II and a pilot study.

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