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Study exclusions included known infection with the human immunodeficiency virus, other prior malignancies within 5 years (unless approved by the principal investigator), pregnancy or nursing, inability or unwillingness to utilize contraceptive techniques while on study, active central nervous system lymphoma, or known disease resistance to carboplatin, cisplatin, or gemcitabine.
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There also can be hirsutism in females and streaked purple markings (atrophic striae) in the abdominal area as a result of collections of body fat.
With a median follow-up of 25 months, this trial showed improved OS for patients in the low-dose dexamethasone arm (87% vs.
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Responding patients could choose after 4 cycles to proceed to or to continue RD until progression of disease or intolerable toxicity; nonresponders were transitioned to (details not described).
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