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It helps to prevent gout attacks by reducing the levels of uric acid in your blood.
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Comparison 5 Allopurinol: continuous versus intermittent, Outcome 1 Acute gout attacks.
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Prevent or reverse complications resulting from deposition of monosodium urate in the joints, in the kidneys, or at other sites.
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Our review did not identify any RCTs that compared allopurinol with probenecid in chronic gout, although did retrieve one CCT at high risk of bias where limited data were presented ().
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In people with chronic gout, compared with benzbromarone (up to 200 mg daily), allopurinol (up to 600 mg daily) may not reduce the number of acute gout attacks (low-quality evidence), probably does not increase the proportion achieving target serum urate levels, or the withdrawals due to AEs or serious adverse event rates (moderate-quality evidence).
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This is to see whether the levels of uric acid are going down with the allopurinol treatment, and by how much.
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In cases where allopurinol (300 to 600 mg daily) is administered with mercaptopurine or azathioprine, a reduction in dose to approximately one-third to one-quarter of the usual dose of mercaptopurine or azathioprine should be made, and subsequent dose adjustment made on the basis of therapeutic response and the appearance of toxic effects.
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One trial including 40 participants, judged to be at high risk of bias, compared allopurinol 300 to 600 mg daily with probenecid (1 g daily increasing to 2 g daily after two weeks) ().
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There was also moderate-quality evidence based on pooled data from these three trials (2556 participants) of no between-group difference in the number of participants with SAEs when allopurinol up to 300 mg daily was compared with febuxostat 80 mg daily over a 24- to 52-week period ().
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