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Is a high INR dangerous? An international normalized ratio (INR) higher than 9 is associated with a high risk of bleeding, yet most studies have focused on outpatients with lower INR. Patients without anticoagulant treatment with INR higher than 9 had a poor prognosis, 67% experienced bleeding and 74% died.
What is the mechanism of action of warfarin? Mechanism of Action Warfarin is thought to interfere with clotting factor synthesis by inhibition of the C1 subunit of the vitamin K epoxide reductase (VKORC1) enzyme complex, thereby reducing the regeneration of vitamin K1 epoxide.
Can drugs affect eyesight? Some drugs come with visual side effects Yet some prescription drugs and even a few over-the-counter remedies can have serious visual side effects. Medications can have a variety of effects on your eyes, ranging from minor, temporary issues such as blurred vision to permanent damage.
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