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Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occur in approximately 1% of patients treated for 3-6 months, and in about 2-4% of patients treated for one year.

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Taking naproxen or other NSAIDs in the third trimester may require that the baby needs to be delivered early.

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The reported difference, if accepted as conclusive, would mean that the PRECISION randomization methodology is no longer reasonable because, given that the participants already have cardiovascular disease or are at risk of developing it, assigning some to receive products known to pose a higher cardiovascular risk than naproxen would be unethical.

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