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The liberated choline from the ACh decomposition is taken up again by the pre-synaptic nerve and the neurotransmitter is synthesized by combining with acetyl-CoA through the action of choline acetyltransferase (Fig.

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The maximum and minimum plasma concentrations achieved in each 24 h observation period ( C max and C min, respectively) and the time that C max occurred relative to the last dose ( t max) were determined directly from the observed data.

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This review included one randomised controlled trial of poor methodological quality involving 64 patients with VaD who were also taking donepezil.

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Besides the expected changes in the production of pro-inflammatory cytokines, we detected alterations in the functioning of the HPA axis, in adrenaline levels in plasma, and in the sensitivity of IL-1 and IL-6 and in the serenity of NA in the hypothalamus.

Parkinson's disease dementia (PDD), where dementia develops at least a year after parkinsonian symptoms, missed primary endpoints but showed signals in secondary analyses ().

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PK interaction of risperidone and donepezil will be invaluable, since risperidone is often used in dementia patients for the treatment of agitation or psychosis, increasing the likelihood that the two drugs may be administered concomitantly.

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Animals were maintained and experiments were conducted in accordance with the Institutional Animal Care and Use Committee, Shenyang Pharmaceutical University, and the 1996 Guide for the Care and Use of Laboratory Animals (Institute of Laboratory Animal Resources on Life Sciences, National Research Council, National Academy of Sciences, Washington DC).

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Progress: More work is needed in this area to achieve the goals set forth by the objective.

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