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OBJECTIVES: The objective of this study was to determine the incidence of bacteremia in febrile sickle cell disease (SCD) children before and after the 7-valent pneumococcal vaccine (PCV7), and to determine clinical factors associated with bacteremia following PCV7.

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Two major approaches are being taken: removal of the sickle pathogenic variant and replacement with a normal sequence; and disruption of regulators of globin gene expression, such as Bcl11a, which in turn results in increased expression of the fetal genes.

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Non-Hodgkin's lymphoma, described first as a complication in chlorambucil-treated patients with polycythemia vera, now has also been reported in a patient with polycythemia vera who was treated with hydroxyurea.

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