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How many mg of Zofran can you take at once? Adults typically take one 8- mg tablet or rapidly disintegrating tablet or 10 mL of liquid twice a day. For patients ages 12 and older, the dosage is the same as for adults. For those ages 4 to 11, patients should take a 4- mg tablet or rapidly disintegrating tablet or 5 mL of liquid three times per day.


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